This Notice of Funding Opportunity (NOFO) invites applications for the Computational Models of Influenza Immunity Cooperative Agreement Program. The program will employ computational modeling and immunologic studies to advance our understanding of the requirements for improving anti-influenza immunity, including inducing broad immune protection and enhancing immune durability. This program will help inform design of universal or improved seasonal flu vaccines. Projects may lead to a better understanding of how pre-existing immunity and repeat exposures (natural infection and/or vaccines) shape an individuals immune landscape. Predictive modeling of adjuvants/vaccine formulations and experimental validation supported by this program should lead to enhanced host immune responses and universal or improved seasonal influenza vaccine efficacy.