HEAL Initiative Integrated Basic and Clinical Team-based Research in Pain(RM1 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Next deadline: Feb 14, 2023 (Full proposal)

Later deadlines: May 14, 2023 (Letter of inquiry), Jun 14, 2023 (Full proposal), Sep 13, 2023 (Letter of inquiry), Oct 13, 2023 (Full proposal), Jan 12, 2024 (Letter of inquiry), Feb 12, 2024 (Full proposal)

Grant amount: Up to US $5,000,000

Fields of work: Chronic / Acute Pain

Applicant type: Government Entity, Nonprofit, For-Profit Business, Indigenous Group

Funding uses: Research

Location of project: Anywhere in the world

Location of residency: Anywhere in the world


This funding opportunity announcement (FOA) is designed to support integrated efforts of three or more (up to six) PDs/PIs to pursue bold, impactful, and challenging research in basic and clinical pain domains to understand the biology of specific human pain conditions as well as pain associated with diverse diseases/disorders, including mechanistic underpinning of heterogeneity and stratification of patients with specific pain conditions and co-morbidities. The research approach should be interdisciplinary in nature, and the research teams are expected to establish a common goal that requires collaboration, synergy, and managed team interactions. Proposed research should not represent a collection of individual efforts or parallel projects. Proposed research should support a cohesive, single, well-integrated research plan with a singular focus, one set of aims, and a budget without subprojects. Teams must leverage appropriate multi-disciplinary expertise to develop new principles and methods for experimentation, analysis, and interpretation. Teams are encouraged to consider transformative objectives with defined 5-year outcomes that will produce major advances in the understanding of human pain conditions and are likely to improve strategies for effective management of human pain.

Application budgets should not exceed $1,000,000 direct costs per year, and should be consistent with the number of PDs/PIs and the complexity and needs of the proposed program. Annual inflationary increases are not allowed. Applications may request up to five years of support.

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This page was last reviewed November 06, 2022 and last updated November 06, 2022