Interaction between ARVs and Hormones in HIV and Coinfections (R01 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

View website Save this grant

Next deadline: Jun 30, 2024 (Letter of inquiry)

Later deadlines: Jul 30, 2024 (Full proposal)

Grant amount: Unspecified amount

Fields of work: HIV/AIDS

Applicant type: Organizations

Funding uses: Research

Location of project: Anywhere in the world

Location of residency: Anywhere in the world

Overview:

NOTE:

  • Letter of Inquiry (Letter of Intent) - This is due 30 days prior to the application due date (due by 5:00 pm local time of applicant organization).
  • The following deadline applies to the AIDS-related grant application (due by 5:00 pm local time of applicant organization): 
    • July 30, 2024

Interaction between ARVs and Hormones in HIV and Coinfections (R01 Clinical Trial Optional)

Purpose

The purpose of this Notice of Funding Opportunity (NOFO) is to support research to identify and characterize the interaction between hormone therapy and antiretroviral drugs (ARVs) used for treatment and prevention of HIV and co-infections.

Research Objectives and Requirements

This program will support projects to identify and characterize factors associated with gender-affirming hormone therapy (GAHT) that may impact/contribute significantly to the prevention and treatment of HIV and/or co-infections with other sexually transmitted infections (STI)s in transgender individuals. For this funding opportunity GAHT is defined as a medical intervention, including but not limited to estrogen and/or testosterone treatment, that results in acquisition of secondary sex characteristics that align with an individual's gender identity. A growing body of data indicates that GAHT may impact the effectiveness and implementation of biomedical HIV prevention or treatment strategies and/or co-infections with other STIs. A number of factors in transgender populations present research challenges including variability in GAHT regimens, use of auxiliary drugs during GAHT care, access to participants, and access to existing cohorts, datasets, and samples. Consideration of appropriate controls, including cis-gender men and women is also a barrier. Recent studies demonstrating recruitment and retention of participants undergoing GAHT provide the opportunity to build on those studies and provide confidence that these critical studies are feasible.

There is no plan to directly compare different types of GAHT per se. Rather the goal is to collect information on the impact of hormone regimens on ARVs for treatment and prevention including monitoring drug levels, pharmacokinetics, metabolism, and potential changes in susceptibility to HIV transmission. While the primary focus will not be direct comparison of GAHT regiments, investigators may observe differences between regimens as they characterize their impact on HIV treatment and prevention.

Research to understand needs and tailoring of programs to transgender people is critical for comprehensive HIV and other STI prevention in this population. Involvement of community representation in the team is needed to provide an accurate understanding of the community specific priorities and biomedical and psychosocial needs for HIV prevention and treatment.

Applicants are encouraged to use existing cohorts, datasets, and samples when possible. Realistic milestones, timelines, and consideration of alternative approaches are critical to the success of the program. Documentation of hormone regimens including self-administered medications will support a comprehensive understanding of effectiveness of HIV prevention and treatment in these populations.

We've imported the main document for this grant to give you an overview. You can learn more about this opportunity by visiting the funder's website.

US Dept. of Health & Human Services: National Institutes of Health (NIH)
FUNDER

Your history with this funder
0
SAVED OPPORTUNITIES
No saved opportunities from this funder yet
FUNDER NOTES
Save this opportunity to add notes...
CONTACTS
Save this opportunity to add contacts...

Other Funding Opportunities from Us Dept. Of Health & Human Services: National Institutes Of Health (Nih)

Forecasted Funding Opportunities from Us Dept. Of Health & Human Services: National Institutes Of Health (Nih) help icon

Don't miss out on other good fit funders!

Get personalized grant recommendations, tracking and more by creating a free 14-day account.

No credit card required.
instrumentl testimonial face

"Winning 30% more grants thanks to Instrumentl was a huge morale boost. My confidence continues to grow."

Linda Rucker, Grant Writer

This page was last reviewed March 29, 2024 and last updated March 29, 2024