New Approaches for Incorporating Genetic Diversity into Toxicity Testing (R43/R44 Clinical Trial Not Allowed) (341632)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Next deadline: Oct 8, 2022 (Letter of inquiry)

Later deadlines: Nov 8, 2022 (Full proposal)

Grant amount: Up to US $275,766

Fields of work: Environmental Chemistry & Toxicology Genetics & Genomics Human Genome & Genetics

Applicant type: For-Profit Business

Funding uses: Research

Location of project: United States

Location of residency: United States


This Funding Opportunity Announcement (FOA) supports Phase I (R43), Phase II (R44), Direct to Phase II (R44), and Fast Track (R44) Small Business Innovative Research (SBIR) grant applications from small businesses concerns (SBCs) to develop resources and approaches, including panels of cells or model organisms, that reflect the variability in human populations in chemical toxicity testing . Current toxicology testing is often limited to studies conducted in a small number of laboratory rodent strains, which can fail to identify clinically relevant toxicity if the conventional rodent strain is particularly resistant to the toxic effects of the test compound. Cost-effective screening systems with appropriate throughput are needed to better capture this variability in responses to chemical exposure in the population based on individual genetic susceptibility.

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This page was last reviewed July 01, 2022 and last updated July 01, 2022