NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Predicted Deadline
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Next predicted deadline: Jan 15, 2024 (Letter of inquiry)

Later predicted deadlines: Feb 15, 2024 (Full proposal)

Grant amount: Up to US $225,000

Fields of work: Diseases & Conditions

Applicant type: Organizations

Funding uses: Research

Location of project: Anywhere in the world

Location of residency: United States, American Samoa, Guam, Northern Mariana Islands, Puerto Rico Show all


NOTE: All applications are due by 5:00 PM local time of applicant organization.  Consultation with NIDDK scientific staff is strongly encouraged prior to the submission of the U34 application.

NIDDK supports investigator-initiated, high-risk multi-center (more than one center) clinical studies through a two-part process that may include an implementation planning cooperative agreement (U34). The U34 is designed to:

  • Permit early peer review of the rationale for the proposed clinical study; 
  • Permit assessment of the design and protocol of the proposed study;
  • Provide support for the development of documents needed for the conduct of the study, including a manual of operations; and
  • Support the development of other essential elements required for the conduct of the clinical study. The proposed clinical study should be hypothesis-driven and focus on a disease in the mission of NIDDK.

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This page was last reviewed May 09, 2023 and last updated May 09, 2023