Notice of Intent to Publish a Funding Opportunity Announcement for Human Tumor Atlas (HTA) Research Centers (U01 Clinical Trial Not Allowed)

FORECAST

US Dept. of Health & Human Services: National Institutes of Health (NIH)

Note: This is a forecasted federal opportunity that has been posted on grants.gov. If you save this grant, we'll notify you of any changes.

Deadline: The deadline for this grant has passed

Grant amount: Up to US $800,000

Funding uses: Training / Capacity Building, Research

Location of project: United States, American Samoa, Guam, Northern Mariana Islands, Puerto Rico, Virgin Islands Show all

Location of residency: United States, American Samoa, Guam, Northern Mariana Islands, Puerto Rico, Virgin Islands Show all

Overview:

The National Cancer Institute (NCI) intends to promote a renewed initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for Human Tumor Atlas (HTA) Research Centers, one of the three scientific components of the Human Tumor Atlas Network (HTAN) (NCI Human Tumor Atlas Network). HTAN is a collaborative research initiative and a community resource generating program that is tasked with generating spatial atlases of cancer transitions for a diverse set of precancers and advanced cancers that build upon the current set of public HTAN atlases. HTAN research will span across pivotal points in tumor evolution that include progression from premalignancy to malignancy, primary tumor to metastasis, locoregional tumor recurrence, and response and resistance to treatment. These atlases will enable the development of new classifiers and risk prediction tools, identification of potential targets for preventive interceptions, enhancement of diagnostic and treatment strategies for advanced cancers, and generation of compelling hypotheses to facilitate future research on underlying biological mechanisms.

It is imperative that the HTAN atlases are clinically useful for the diverse populations in the United States and the construction process must be mindful of this important aspect. The NOFO will utilize the U01 (Research Project - Cooperative Agreements; Clinical Trial Not Allowed) activity code. Each HTA Research Center will construct one human precancer or advanced cancer atlas describing one or more transitions spanning the entire cancer continuum: precancer to locally invasive cancer to metastatic cancer, locoregional recurrence, dynamic response to therapy, and development of therapeutic resistance. The atlas efforts must leverage and expand upon the current HTAN resources and infrastructure and focus on creating spatial atlases at single-cell resolution that are driven by specific topics in cancer biology. Research Centers will collaborate with other PCA and HTA Research Centers and the HTAN Data Coordinating Center (DCC). Research Centers will work with the DCC to make the data and analytical tools available to the research community.

You can learn more about this opportunity by visiting the funder's website.