This Funding Opportunity Announcement (FOA) provides support to eligible, domestic institutions to develop and implement Postbaccalaureate Research Education Programs in Diabetes, Endocrinology and Metabolic Diseases (DDEMD). These post-baccalaureate research programs will incorporate extensive research experiences and well-designed courses for skills development to prepare recent college graduates from diverse backgrounds to transition into and complete rigorous, research-focused biomedical doctoral degree programs (e.g., Ph.D. or M.D./Ph.D.). The long-term goal of post-baccalaureate participants admitted to the program should be pursuing a career focused on DDEMD-related research. Eligible applicants for the R25 must be research-intensive doctoral degree-granting institutions with a research base in DDEMD science of at least $3 million in direct costs of peer-reviewed research projects, and research opportunities for students admitted to the program must be in DDEMD science.