Precision Mental Health: Develop Tools to Inform Treatment Selection in Depression (UG3/UH3 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)

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Deadline: Oct 18, 2024 (Full proposal)

Grant amount: Up to US $8,500,000

Fields of work: Mental Health & Psychiatric Diseases Depression/Anxiety

Applicant type: Nonprofit, Government Entity, Indigenous Group, For-Profit Business

Funding uses: Research, Project / Program

Location of project: Anywhere in the world

Location of residency: Anywhere in the world


NOTE: All applications are due by 5:00 PM local time of applicant organization. 

The goal of this phased FOA (either R33/R61 or UG3/UH3) is to accelerate the development of sensitive biomarkers/tools to predict individual treatment-response between two or more existing treatments for depression. In phase 1 (up to 2 years) preliminary studies (e.g., retrospective secondary analyses of data from completed clinical trials and/or in nimble, fast-fail pilot studies) will de-risk the test technology demonstrating that there is enough signal for clinical utility (futility analyses, ROC curves, and/or effect size will be evaluated as go/no-go criteria). Phase 2 (up to 5 years) innovators will prospectively test the efficacy of the biomarker/tool in large-scale biomarker/tool-stratified clinical trials with the goal of beating standard-of-care decision-making (i.e., clinician/patient treatment assignment will be the CTRL group vs the test).

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US Dept. of Health & Human Services: National Institutes of Health (NIH)

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This page was last reviewed June 06, 2023 and last updated June 05, 2023